Start your day with eggs Benedict—two poached eggs, Canadian bacon, asparagus and Hollandaise sauce on crusty French bread—at Manna Java World Cafe.
At the National Mississippi River Museum and Aquarium, stroll through the Rivers of America exhibit, watch a boatbuilder at work, and catch a featured film at the 3D/4D theater.
Enjoy Cajun cornmeal catfish along with Mississippi River views at Catfish Charlie's.
Visit the Dubuque Museum of Art’s noted Grant Wood Gallery.
Relax with a tasting of Stone Cliff Winery’s best-selling Riesling and Moscato wines; take home a wine glass as souvenir.
L. May Eatery serves pizzas with toppings like artichokes, homemade pickles and steak.
Kids in tow? Stay where they can splash in Grand Harbor Resort and WaterPark's indoor water park (from $99) along the Mississippi Riverwalk. Or end your day at the boutique Hotel Julien Dubuque (from $159).
For $1.50 each way, ride up the Fenelon Place Elevator, the world’s shortest, steepest scenic railway. The tristate view from the top of the bluff is magnificent.
Don’t miss the award-winning rose gardens at the Dubuque Arboretum and Botanical Gardens, the largest all-volunteer arboretum in the country.
Take a break at Chocolaterie Stam/Corked, a European-style chocolate shop selling handcrafted chocolates, gelato, coffees and wines.
From atop Eagle Point Park’s bluffs (overlooking the Mississippi River and Lock & Dam No. 11) take in the spectacular tristate view of Iowa, Wisconsin and Illinois.
More information: (800) 798-8844; traveldubuque.com