50 Instant Itineraries | Midwest Living

50 Instant Itineraries

Not much time to travel? Explore the Midwest on weekends or short weekday trips with our two-day getaway itineraries.
Historic Mayo Clinic. Photo by Kendra L. Williams.

Rochester, Minnesota

Home to the world-renowned Mayo Clinic, Rochester was providing topnotch TLC long before medical tourism became a trend. It also has hospitality down to a science, welcoming visitors with classy cuisine, chic shopping, sophisticated galleries and close to 5,000 hotel rooms. Explore the history and architecture of the Mayo Clinic, and learn more about the Mayo family legacy while touring Mayowood Mansion. 

See our two-day Rochester itinerary.

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