45 Best New Midwest Spots to Play, Eat & Stay: 2010
Missouri: Moonrise Hotel in St. Louis, Castle Rock Resort and Waterpark in Branson, Raphael in Kansas City
Moonrise Hotel: Yes, that's a big, cratered moon spinning atop St. Louis' newest boutique hotel, located in the Delmar Loop. And you'll find more lunar art in the spacious rooms and lobby -- a perfect balance of kitsch and comfort. From $139 (314/721-1111).
Raphael: A $20 million renovation has turned this Spanish Renaissance Revival-style property into a warm and inviting space to snuggle, right near Country Club Plaza. From $159 (800/821-5343).
Castle Rock Resort and Waterpark: Branson welcomes its third (and largest) indoor water park at this newly expanded hotel just off the Strip. From $99 (888/273-3919).
Pictured: Moonrise Hotel in St. Louis.