Rocheport Shops, inns and cafes cater to cyclists on the Katy Trail (left).
Hannibal Fact and fiction blur in Mark Twain's hometown on the Mississippi River, with tours of his home, Tom Sawyer's cave, riverboat rides and Twain shows.
Sainte Genevieve See amazing French Colonial architecture in one of the oldest settlements west of the Mississippi River.
Fulton There's an arresting vibe at Westminster College, the site of Winston Churchill's "Iron Curtain" speech and home of a Berlin Wall segment.
Hermann It seems like you're right on the Rhine in this German village, but you're not. You're in Hermann, a hub for Missouri River wine country and cyclists' beloved Katy Trail.
Weston This is a time capsule of a town rich in pre-Civil War history with shops, museums and old homes.
Carthage Civil War and Route 66 sites are here, as well as George Washington Carver's home.
Arrow Rock This town is home to the 1834 Arrow Rock Tavern and the respected Lyceum Theatre.
Kimmswick Twenty-five shops and 94 people are in this Mississippi hamlet south of St. Louis; riverboat rides from St. Louis are offered in the summer.
Rocheport
Hermann
Hannibal
Sainte Genevieve
Fulton
Weston
Carthage
Arrow Rock
Kimmswick
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