Does your idea of a warm-weather vacation involve 200 golf courses, innovative spas and 330 days of annual sunshine? Then head to Scottsdale, Arizona. Just outside of Phoenix, this desert oasis delivers the perfect occasion to break out the clubs, develop your inner Zen and explore the sprawling Sonoran Desert (800/782-1117; experiencescottsdale.com).
Healing springs have long been the draw to Eureka Springs, Arkansas. In the 1800s, visitors drank from town's famous mineral springs. Today, healing waters take center stage at the town's spas, such as the Palace Hotel Bath House, where The Works gets you a private soak, a steam, mask and massage in this gorgeous historic bath house. Starting at $80, the prices seem historic, too (866/947-4387; eurekasprings.org).
Southern hospitality extends even to alligators in Hilton Head, South Carolina, where it's not uncommon to see the large lizards basking on area golf courses. Follow their cue and stay awhile. Although it's only 12 miles long and 5 miles wide, the area is packed with 250 restaurants, 24 golf courses, 80 miles of bike trails and numerous picturesque beaches. You're surrounded by warm-weather action here (800/523-3373; hiltonheadisland.org).
Ready to migrate south for the winter? Go where the birds go—Louisiana. The Creole Nature Trail All-American Road, aka Louisiana's Outback, begins in Lake Charles and provides 180 miles of stage for bird sightings, with regular appearances by 400 species, including pelicans, egrets, herons and more. Sample seafood fresh from the warm Gulf waters along the way, and your trip through the Bayou State is complete (800/456-7952; creolenaturetrail.org).
Creole Natural Trail 
Golf season is year-round in Dallas, Texas, so escape the snow and head for the greens. Try your swing at the TPC Four Seasons Las Colinas, home to the annual PGA Tour event HP Byron Nelson Championship, and show those Texans that Midwesterners can rule the links—even though our courses happen to be frozen right now (800/232-5527; visitdallas.com).
Flee the ice-fishing holes of the Midwest this winter and head south to the breezy sunshine of Port Arthur, Texas. Your winter blues will melt away at the 14-mile-long Sabine Lake, which is chockablock with flounder, speckled trout and redfish. Don't feel like catching them yourself? There are plenty of area seafood restaurants willing to do the work for you (800/235-7822; visitportarthurtx.com).
Need to hit the spiritual reset button? Sedona, Arizona, is ready to help. If a yogi ran a national park, it would look like this red-rock-tinged Nirvana. Brimming with spiritual healers, aura readers, spas, vortex sites, yoga and limitless outdoor activities—hiking, biking, jeep tours and more—Sedona will heal you on many levels. And the endless sunshine doesn't hurt, either (800/288-7336; visitsedona.com).
You don't have to go all the way to Napa Valley to taste wonderful California wine. A number of reputable wineries (Ferrara, Orfila, Hawk Watch, Shadow Mountain Vineyards) make their home just outside of San Diego and are open for tastings. Add daytime highs in the mid-60s, endless spas, beautiful beaches, world-renowned restaurants and, of course, no snow, and you have the perfect cure to winter (619/232-3101; sandiego.org).
The Fort Worth Cultural District is home to five museums. Admire extraordinary art at the Louis I. Kahn-designed Kimbell Art Museum, wax contemporary at the Modern Art Museum of Fort Worth, go American at Amon Carter Museum of American Art, and find the best of both worlds at Museum of Science and History. And, of course, nothing completes a Fort Worth trip like the National Cowgirl Museum. Yee-haw! (800/433-5747; fortworth.com).